The role of FOXL2, SOX9, and β-catenin expression and DICER1 mutation in differentiating sex cord tumor with annular tubules from other sex cord tumors of the ovary

Sex cord tumor with annular tubules (SCTAT) is a highly rare type of ovarian sex cord-stromal (SCST), the diagnosis which remains to be challenging. The aim this study was scrutinize utility three immunohistochemical markers including Forkhead box protein 2 (FOXL2), SOX9, and β-catenin DICER1 mutation status in distinguishing SCTATs from other SCSTs. Nine cases SCTAT, 10 Sertoli-Leydig cell (SCLT), adult-type granulosa (AGCT), 8 juvenile-type (JGCT) were included study. characterized by diffuse strong expression focal weak FOXL2, absence mutation. However, AGCTs JGCTs displayed focal/no immunoreaction for SOX9. SLCTs generally showed moderate intensity FOXL2 SOX9 expression. Nuclear observed none SLCT, 1/9 6/8 JGCT, 4/10 AGCT cases, respectively. hotspot detected only 3 SLCT JGCT. We conclude that addition expression, weak/absent suggestive SCTAT. Hence, we suggest inclusion these two markers, SOX-9 panel helps differentiation SCTAT SCSTs morphologic findings. also ovary do not harbor